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I assume this is related to your other question.
When creating Interface Endpoints for services such as SES you don't need to modify the route table. When you create the endpoint you nominate the subnets where you want the endpoint to be created. Because the endpoints use a local IP address there is no need to change the route table.
When you call the SES service the credentials used will be that of the Lambda function or EC2 instance - you can assign a role to each of those with the appropriate permissions. That's assuming you are calling the SES API using boto3.
If you are using port 25/587 then you will need NAT Gateway to reach the SES endpoint. Definitely easier to use the endpoint and boto3 in my opinion.
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