Route 53 record for different region

Take a look at Route 53 Private Hosted Zone.

Hi

So the best way to do this is have a regional DNS entry for each region you are using.
Then apply a global DNS entry that routes to the correct region and applies routing policies to direct traffic. This way you can test each region and manage traffic to each region.

This blog on multi-region HA might help. https://aws.amazon.com/blogs/networking-and-content-delivery/building-highly-resilient-applications-using-amazon-route-53-application-recovery-controller-part-2-multi-region-stack/
Specifically take a look at the section "Failing over user traffic". This shows how you can have regional and global DNS.

Hope this helps.