How to invoke Bedrock Claude models in eu-west-1? Getting "Invocation with on-demand throughput isn't supported"

Question

I'm trying to invoke `anthropic.claude-sonnet-4-20250514-v1:0` from a Lambda function in eu-west-1 using the Python SDK:

```python
bedrock = boto3.client('bedrock-runtime')
response = bedrock.invoke_model(
    modelId="anthropic.claude-sonnet-4-20250514-v1:0",
    contentType="application/json",
    accept="application/json",
    body=json.dumps({...})
)
```

I'm getting this error:

```
ValidationException: Invocation of model ID anthropic.claude-sonnet-4-20250514-v1:0 
with on-demand throughput isn't supported. Retry your request with the ID or ARN of 
an inference profile that contains this model.
```

My IAM policy allows `bedrock:InvokeModel` on `arn:aws:bedrock:*::foundation-model/anthropic.*`. What am I missing?

re:Post Agent · Accepted Answer

The error you're encountering indicates that the specific Claude model you're trying to use requires an inference profile rather than direct model invocation. This is particularly relevant for newer Claude models that use cross-Region inference capabilities.

To resolve this issue, you need to use an inference profile ID instead of the direct model ID. Based on your region (eu-west-1), you should use a geographic cross-Region inference profile or a global inference profile.

Here's how to update your code:

```python
import boto3
import json

bedrock = boto3.client('bedrock-runtime', region_name='eu-west-1')

# Use an inference profile ID instead of the direct model ID
model_id = "eu.anthropic.claude-sonnet-4-20250514-v1:0"  # Geographic profile
# OR use global profile: "global.anthropic.claude-sonnet-4-20250514-v1:0"

response = bedrock.invoke_model(
modelId=model_id,
contentType="application/json",
accept="application/json",
body=json.dumps({...})
)
```

The key change is replacing your model ID with an inference profile ID that starts with a geographic prefix (like `eu.`) or `global.` instead of just `anthropic.`.

Additionally, you'll need to update your IAM policy to include permissions for cross-Region inference. Your policy should allow `bedrock:InvokeModel` on inference profile ARNs, not just foundation model ARNs. Make sure your IAM role or user has the necessary permissions to invoke Amazon Bedrock models using a cross-Region inference profile.

The inference profile automatically routes your requests to the optimal Region with available capacity, which helps with throughput and resilience while maintaining your data in compliant Regions when using geographic profiles.  
**Sources**  
[Introducing Amazon Bedrock global cross-Region inference for Anthropic’s Claude models in the Middle East Regions (UAE and Bahrain) | Artificial Intelligence](https://aws.amazon.com/blogs/machine-learning/introducing-amazon-bedrock-global-cross-region-inference-for-anthropics-claude-models-in-the-middle-east-regions/)  
[Unlock global AI inference scalability using new global cross-Region inference on Amazon Bedrock  with Anthropic’s Claude Sonnet 4.5 | Artificial Intelligence](https://aws.amazon.com/blogs/machine-learning/unlock-global-ai-inference-scalability-using-new-global-cross-region-inference-on-amazon-bedrock-with-anthropics-claude-sonnet-4-5/)

Lucky · Answer

In certain regions (including eu-west-1), newer Bedrock models cannot be invoked directly by model ID. You must use an **inference profile** instead.

### Step 1: Find the available inference profile

```bash
aws bedrock list-inference-profiles --region eu-west-1 \
  --query "inferenceProfileSummaries[?contains(inferenceProfileName, 'Sonnet')].[inferenceProfileId,inferenceProfileName]" \
  --output table
```

This will show profiles like:
- `eu.anthropic.claude-sonnet-4-20250514-v1:0` — EU regional profile
- `global.anthropic.claude-sonnet-4-20250514-v1:0` — Global cross-region profile

### Step 2: Use the inference profile ID instead of the model ID

```python
response = bedrock.invoke_model(
    modelId="eu.anthropic.claude-sonnet-4-20250514-v1:0",  # inference profile, not model ID
    contentType="application/json",
    accept="application/json",
    body=json.dumps({...})
)
```

### Step 3: Update your IAM policy

The inference profile has a different ARN format than foundation models:

```json
{
  "Effect": "Allow",
  "Action": "bedrock:InvokeModel",
  "Resource": [
    "arn:aws:bedrock:*::foundation-model/anthropic.*",
    "arn:aws:bedrock:eu-west-1:ACCOUNT_ID:inference-profile/eu.anthropic.*"
  ]
}
```

Note the inference profile ARN includes your account ID and region, unlike foundation model ARNs.

### Why this happens

AWS uses inference profiles to manage regional routing and capacity for newer models. The EU profile (`eu.`) routes requests to EU-based infrastructure, while the global profile (`global.`) can route cross-region. The direct model ID only works in regions where on-demand throughput is explicitly supported for that model.

### References

- [Amazon Bedrock inference profiles](https://docs.aws.amazon.com/bedrock/latest/userguide/inference-profiles.html)
- [Cross-region inference](https://docs.aws.amazon.com/bedrock/latest/userguide/cross-region-inference.html)

How to invoke Bedrock Claude models in eu-west-1? Getting "Invocation with on-demand throughput isn't supported"

Step 1: Find the available inference profile

Step 2: Use the inference profile ID instead of the model ID

Step 3: Update your IAM policy

Why this happens

References

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