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What instance type are you running? My guess would be the MySQL workload is gradually consuming more and more resources until it's reached a point that there's nothing left, and as a result the host is basically hanging.
Check the Monitoring tab for the instance in AWS Console, is there anything that looks like a cause for concern?
Unfortunately the EC2 section of the AWS Console doesn't display metrics for memory use, you'll need to setup CloudWatch agent to collect these https://docs.aws.amazon.com/AmazonCloudWatch/latest/monitoring/Install-CloudWatch-Agent.html
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r5.2xlarge,But no problems were found by checking /var/log/message, such as "OOM",,,
answered 2 years ago
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