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No, changing that setting couldn't have caused all the effects you're describing.
I suggest you first check that the region selection in the upper right-hand corner of the console view is set to the correct region, and ensure that the correct region continues to be selected when you're looking for the RDS instances in the RDS console, for example.
If you've selected or been defaulted to a different region, the EC2 instance you're seeing wouldn't be the one whose IP address settings you modified but a completely different instance. That would explain why the security group associations aren't meeting your expectations. It would also explain why you aren't seeing any RDS databases in the console: they would still exist but in the region where they reside and not the region you're viewing.
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asked 4 years ago

You were absolutely right! I found a region where all my resources were still there. You have no idea how much I appreciate it. Everything is working now. Thanks a lot!