How to clear Server cache in EC2

Best way is to schedule cronjob to clean up the cache. Below cronjob commands are to clear the server cache every hour. Please change it according to your needs.

1 * * * * sync; echo 3 > /proc/sys/vm/drop_caches 1 * * * * sync; echo 2 > /proc/sys/vm/drop_caches 1 * * * * sync; echo 1 > /proc/sys/vm/drop_caches

You've mentioned a server cache in EC2 but added "Amazon File Cache" as a tag - are you actually using this? https://aws.amazon.com/filecache/faqs/.

If it's a server cache on EC2, wht are you caching and what are you using to perform the caching?